Mediation of Drosophila autosomal dosage effects and compensation by network interactions
نویسندگان
چکیده
منابع مشابه
Dosage compensation in Drosophila.
Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X. Nucleation and sequence-independent spreading of the complex to active ge...
متن کاملAnalysis of autosomal dosage compensation involving the alcohol dehydrogenase locus in Drosophila melanogaster.
An example of autosomal dosage compensation involving the expression of the alcohol dehydrogenase (Adh) locus is described. Flies trisomic for a quarter of the length of the left arm of chromosome two, including Adh, have diploid levels of enzyme activity and alcohol dehydrogenase messenger RNA. Subdivision of the compensating trisomic into smaller ones revealed a region that exerts an inverse ...
متن کاملLack of dosage compensation for an autosomal gene relocated to the X chromosome in Drosophila melanogaster.
Aldehyde oxidase activity has been measured in flies with the structural gene for this enzyme translocated to the X chromosome. These measurements are presented as experimental evidence that, in Drosophila melanogaster, an autosomal gene relocated to the X chromosome is not dosage compensated.
متن کاملTargeting Determinants of Dosage Compensation in Drosophila
The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females. Visualization of the DCC, a large ribonucleoprotein complex, on male larval polytene chromosomes reveals that the complex binds selectively to many interbands on the X chromosome. The t...
متن کاملStudy of dosage compensation in Drosophila.
Using a sensitive RT-QPCR assay, we analyzed the regulatory effects of sex and different dosage compensation mutations in Drosophila. To validate the assay, we showed that regulation for several genes indeed varied with the number of functional copies of that gene. We then confirmed that dosage compensation occurred for most genes we examined in male and female flies. Finally, we examined the e...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2012
ISSN: 1465-6906
DOI: 10.1186/gb-2012-13-4-r28